Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis.
Caroline A CrowtherPhilippa F MiddletonMerryn VoyseyLisa AskieSasha ZhangTanya K MartlowFariba AghajafariElizabeth V AsztalosPeter BrocklehurstSourabh DuttaThomas J GariteDebra A GuinnMikko HallmanPollyanna HardyMen-Jean LeeKimberley MaurelPremasish MazumderCindy T McEvoyKellie E MurphyOuti M PeltoniemiElizabeth A ThomRonald J WapnerLex W Doylenull nullPublished in: PLoS medicine (2019)
In this study, we found that repeat prenatal corticosteroids given to women at ongoing risk of preterm birth after an initial course reduced the likelihood of their infant needing respiratory support after birth and led to neonatal benefits. Body size measures at birth were lower in infants exposed to repeat prenatal corticosteroids. Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.
Keyphrases
- preterm birth
- gestational age
- pregnant women
- low birth weight
- pregnancy outcomes
- systematic review
- polycystic ovary syndrome
- type diabetes
- electronic health record
- cervical cancer screening
- meta analyses
- randomized controlled trial
- machine learning
- combination therapy
- insulin resistance
- artificial intelligence
- preterm infants
- respiratory tract