LncRNA XIST modulates miR-328-3p ectopic expression in lung injury induced by tobacco-specific lung carcinogen NNK both in vitro and in vivo.

Bingxin LiXuezheng LiZhe JiangDi ZhouYuan FengGang ChenNing Li

Published in: British journal of pharmacology (2024)

Our results highlight the promotive effect of lncRNA XIST in NNK-induced lung injury and elucidate its post-transcriptional mechanisms, indicating that targeting lncRNA XIST/miR-328-3p could be a potential therapeutic strategy to prevent tobacco carcinogen-induced lung injury in vivo.

Keyphrases

high glucose
long non coding rna
diabetic rats
poor prognosis
long noncoding rna
drug induced
gene expression
endothelial cells
transcription factor
drug delivery
heat shock