Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis.
Guangbo ChenGail H DeutschGrant S SchulertHong ZhengSoRi JangBruce C TrapnellPui Y LeeClaudia MacaubasKatherine HoCorinne SchneiderVivian E SaperAdriana Almeida de JesusMark A KrasnowAlexei GromRaphaela Goldbach ManskyPurvesh KhatriElizabeth D MellinsScott W CannaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Serum proteins support a systemic JIA-to-MAS continuum; help distinguish systemic JIA, systemic JIA/MAS, and SJIA-LD; and suggest etiologic hypotheses. Select biomarkers, such as ICAM-5, could aid in early detection and management of SJIA-LD.