Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters.
Ana Karolinne da Silva BritoGeovanni de Morais LimaLuciana Melo de FariasLays Arnaud Rosal Lopes RodriguesVanessa Brito Lira de CarvalhoCristian Francisco de Carvalho PereiraKaroline de Macedo Gonçalves FrotaAirton Mendes Conde-JúniorAna Mara Oliveira SilvaMarcia Dos Santos RizzoClarisse Maria Barbosa FonsecaRayane Carvalho de MouraRaimunda Cardoso Dos SantosJosé Roberto de Souza de Almeida LeiteMarcos Antônio Pereira Dos SantosPaulo Humberto Moreira NunesDaniel Dias Rufino ArcanjoMaria do Carmo de Carvalho E MartinsPublished in: Nutrients (2019)
This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit (Psidium guajava L.) on the lipid profile and oxidative stress in an experimental model of dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed with the AIN 93G diet containing casein (20%), coconut fat (13.5%) and cholesterol (0.1%). The animals were divided into four groups: normolipidemic control (standard feed; NC, n = 7); hypercholesterolemic control (HC, n = 7); LRE 25 mg/kg/day (LRE-25, n = 7) and LRE 50 mg/kg/day (LRE-50, n = 9). After treatment, plasma concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol (LDL-c), high-density lipoprotein (HDL) cholesterol (HDL-c), malondialdehyde (MDA-p) and myeloperoxidase (MPO), as well as erythrocytic superoxide dismutase (SOD-e) and the atherogenic index, were determined. Malondialdehyde (MDA-h), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD-h) levels were assessed. Feed intake (FI) and weight gain (WG) were also determined. The LRE-25 group presented significantly lower TG levels and atherogenic index than did the HC group (p < 0.05). Both LRE-25 and LRE-50 groups presented lower levels of MDA-p and MPO than did the HC group (p < 0.05). LRE demonstrated a promising effect against dyslipidemia and oxidative stress.
Keyphrases
- low density lipoprotein
- oxidative stress
- high density
- weight gain
- diabetic rats
- dna damage
- breast cancer cells
- hydrogen peroxide
- ischemia reperfusion injury
- body mass index
- induced apoptosis
- adipose tissue
- weight loss
- physical activity
- amyotrophic lateral sclerosis
- cell proliferation
- fatty acid
- high glucose
- signaling pathway
- birth weight
- cell cycle arrest