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Bayesian semi-parametric inference for clustered recurrent events with zero inflation and a terminal event.

Xinyuan TianMaria CiarleglioJiachen CaiErich J GreeneDenise EssermanFan LiYize Zhao
Published in: Journal of the Royal Statistical Society. Series C, Applied statistics (2024)
Recurrent events are common in clinical studies and are often subject to terminal events. In pragmatic trials, participants are often nested in clinics and can be susceptible or structurally unsusceptible to the recurrent events. We develop a Bayesian shared random effects model to accommodate this complex data structure. To achieve robustness, we consider the Dirichlet processes to model the residual of the accelerated failure time model for the survival process as well as the cluster-specific shared frailty distribution, along with an efficient sampling algorithm for posterior inference. Our method is applied to a recent cluster randomized trial on fall injury prevention.
Keyphrases
  • primary care
  • machine learning
  • randomized controlled trial
  • deep learning
  • clinical trial
  • electronic health record
  • big data
  • community dwelling
  • finite element