Antimicrobial peptides modulate lung injury by altering the intestinal microbiota.

Ahmed S Abdelgawad Teodora Nicola Isaac Martin Brian A Halloran Kosuke Tanaka Comfort Y Adegboye Pankaj JainChangchun RenCharitharth Vivek Lal Namasivayam Ambalavanan Amy E O'Connell Tamas Jilling Kent A Willis

Published in: bioRxiv : the preprint server for biology (2023)

Supraphysiologic oxygen exposure alters intestinal antimicrobial peptides (AMPs).Intestinal AMP expression has an inverse relationship with the severity of lung injury.AMP-driven alterations in the intestinal microbiota form a gut-lung axis that modulates lung injury.AMPs may mediate a gut-lung axis that modulates lung injury.

Keyphrases

protein kinase
poor prognosis
long non coding rna
binding protein