Metabolic impairments associated with type 2 diabetes mellitus and the potential effects of exercise therapy: An exploratory randomized trial based on untargeted metabolomics.
Furong ZhangXixi ChenMingxiao YangXiaoyu ShenYiliang WangDongling ZhongFang ZengRongjiang JinPublished in: PloS one (2024)
T2DM patients displayed impaired carbohydrate, lipid, and amino acid metabolism, and exercise therapy improved their metabolic health. Different modalities may act through different pathways. Tai Chi may improve disrupted BCAAs metabolism, whereas brisk walking mainly regulates steroid hormone biosynthesis and arachidonic acid metabolism.
Keyphrases
- end stage renal disease
- mass spectrometry
- high intensity
- amino acid
- ejection fraction
- chronic kidney disease
- healthcare
- public health
- newly diagnosed
- physical activity
- mental health
- peritoneal dialysis
- type diabetes
- glycemic control
- stem cells
- risk assessment
- adipose tissue
- high resolution
- human health
- metabolic syndrome
- fatty acid
- climate change
- insulin resistance
- skeletal muscle
- mesenchymal stem cells
- patient reported
- resting state
- gas chromatography