Updates of colorectal cancer liver metastases therapy: review on DEBIRI.
Giammaria FiorentiniDonatella SartiRoberto NaniCamillo AlibertiCaterina FiorentiniStefano GuadagniPublished in: Hepatic oncology (2020)
Colorectal cancer is a worldwide public health issue, presenting an advanced stage at diagnosis in more than 20% of patients. Liver metastases are the most common metastatic sites and are not indicated for resection in 80% of cases. Unresectable colorectal cancer liver metastases that are refractory to systemic chemotherapy may benefit from transarterial chembolization with irinotecan-loaded beads (DEBIRI). Several studies show the safety and efficacy of DEBIRI for the treatment of colorectal cancer liver metastases. The development of transarterial chembolization and the introduction of new embolics have contributed to better outcomes of DEBIRI. This article reviews the current literature on DEBIRI reporting its use, efficacy in terms of tumor response and survival and side effects.
Keyphrases
- liver metastases
- public health
- end stage renal disease
- systematic review
- newly diagnosed
- small cell lung cancer
- squamous cell carcinoma
- chronic kidney disease
- drug delivery
- prognostic factors
- randomized controlled trial
- peritoneal dialysis
- emergency department
- stem cells
- type diabetes
- locally advanced
- metabolic syndrome
- radiation therapy
- combination therapy
- patient reported outcomes
- skeletal muscle
- electronic health record
- glycemic control