Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids.

Yoshihiro AkitaMasaaki HigashiyamaChie KuriharaSuguru ItoShin NishiiAkinori MizoguchiKenichi InabaRina TanemotoNao SugiharaYoshinori HanawaAkinori WadaKazuki HoriuchiYoshikiyo OkadaKazuyuki NarimatsuShunsuke KomotoKengo TomitaFumie TakeiYasushi SatohMasayuki SarutaRyota Hokari

Published in: Digestive diseases and sciences (2022)

Hydrogen-rich water ameliorated NSAID-induced enteropathy, not only via direct antioxidant effects but also via anti-inflammatory effects by increasing luminal SCFAs. These results suggest that hydrogen may have therapeutic potential in small intestinal inflammatory diseases.

Keyphrases

high glucose
diabetic rats
oxidative stress
fatty acid
drug induced
cell death
visible light
reactive oxygen species