Untargeted metabolomics profiling in pediatric patients and adult populations indicates a connection between lipid imbalance and epilepsy.
Kaisa Teele OjaMihkel IlissonKarit ReinsonKai MuruTiia ReimandHedi PetersonDmytro FishmanTõnu EskoToomas HallerJaanika KronbergMonica Hsiung WojcikAdam D KennedyGregory MichelottiAnne H O'Donnell-LuriaEve Õiglane-ŠlikSander PajusaluKatrin ÕunapPublished in: medRxiv : the preprint server for health sciences (2023)
Our results suggest that cell membrane fluidity may have a significant role in the mechanism of epilepsy, and changes in lipid balance may indicate epilepsy. However, further studies are needed to evaluate whether untargeted metabolomics analysis could prove helpful in diagnosing epilepsy earlier.