Acetazolamide for acute kidney injury in patients undergoing high dose methotrexate therapy: a systematic review and meta-analysis.
Truong Hong HieuSwetha ReddyMariam CharkvianiNasrin NikravangolsefidJacob NinanLeslie HassettKianoush Banaei KashaniJuan Pablo DomecqPublished in: Journal of nephrology (2024)
This systematic review showed no significant difference between acetazolamide and standard care treatment regarding urine alkalinization time and AKI rate in adult patients receiving high dose methotrexate. We suggest performing a large blinded, randomized, controlled trial to evaluate the potential benefits of this low-cost medication.
Keyphrases
- high dose
- low cost
- systematic review
- randomized controlled trial
- stem cell transplantation
- low dose
- patients undergoing
- healthcare
- study protocol
- meta analyses
- acute kidney injury
- palliative care
- clinical trial
- quality improvement
- combination therapy
- human health
- risk assessment
- adverse drug
- mesenchymal stem cells
- chronic pain
- placebo controlled
- double blind