Immunoproteasome subunit β5i promotes perifascicular muscle atrophy in dermatomyositis by upregulating RIG-I.

Lu ZhangQisheng XiaWenli LiQingyan LiuLining ZhangXiaolan TianLifang YeGuochun WangQing-Lin Peng

Published in: RMD open (2023)

The immunoproteasome subunit β5i promotes perifascicular muscle atrophy in DM via RIG-I upregulation; our findings suggest a pathomechanistic role of β5i and RIG-I in DM-associated muscle damage, highlighting these components as potential therapeutic targets for the treatment of DM.

Keyphrases

skeletal muscle
poor prognosis
cell proliferation
interstitial lung disease
signaling pathway
type diabetes
rheumatoid arthritis
disease activity
climate change
adipose tissue
idiopathic pulmonary fibrosis