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Immunoproteasome subunit β5i promotes perifascicular muscle atrophy in dermatomyositis by upregulating RIG-I.

Lu ZhangQisheng XiaWenli LiQingyan LiuLining ZhangXiaolan TianLifang YeGuochun WangQing-Lin Peng
Published in: RMD open (2023)
The immunoproteasome subunit β5i promotes perifascicular muscle atrophy in DM via RIG-I upregulation; our findings suggest a pathomechanistic role of β5i and RIG-I in DM-associated muscle damage, highlighting these components as potential therapeutic targets for the treatment of DM.
Keyphrases
  • skeletal muscle
  • poor prognosis
  • cell proliferation
  • interstitial lung disease
  • signaling pathway
  • type diabetes
  • rheumatoid arthritis
  • disease activity
  • climate change
  • adipose tissue
  • idiopathic pulmonary fibrosis