Neurotropin® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response.
Xuan ZhouHiroki IidaYugiang LiAkinobu OtaLisheng ZhuoReiko NobuharaYuki TerajimaMitsuru NaikiA Hari ReddiKoji KimataTakahiro UshidaPublished in: Molecular pain (2024)
The administration of NTP to the hind paws of mice with painful scar formation following surgery diminished nociceptive pain and reduced the inflammatory response. NTP inhibited the expression of some genes involved in the response to surgery-induced inflammation. Therefore, NTP is a potential therapeutic option for painful scar associated with chronic pain.
Keyphrases
- chronic pain
- inflammatory response
- mouse model
- minimally invasive
- gene expression
- coronary artery bypass
- pain management
- lipopolysaccharide induced
- lps induced
- wound healing
- toll like receptor
- poor prognosis
- surgical site infection
- oxidative stress
- diabetic rats
- high glucose
- neuropathic pain
- type diabetes
- drug induced
- immune response
- coronary artery disease
- adipose tissue
- insulin resistance