The diabetic myocardial transcriptome reveals Erbb3 and Hspa2 as a novel biomarkers of incident heart failure.
Marcella S Conning-RowlandMarilena GiannoudiMichael DrozdOliver I BrownNadira Y YuldashevaChew W ChengPaul J MeakinSam StrawJohn GierulaRamzi A AjjanMark T KearneyEylem LeveltLee D RobertsKathryn J GriffinRichard M CubbonPublished in: Cardiovascular research (2024)
DM is characterized by lower Erbb3 and higher Hspa2 expression in the myocardium, with directionally concordant differences in their plasma protein concentration. These are associated with left ventricular dysfunction, incident heart failure and cardiovascular mortality.
Keyphrases
- heart failure
- left ventricular
- cardiac resynchronization therapy
- cardiovascular disease
- heat shock protein
- tyrosine kinase
- hypertrophic cardiomyopathy
- poor prognosis
- acute myocardial infarction
- binding protein
- aortic stenosis
- cardiovascular events
- left atrial
- type diabetes
- mitral valve
- gene expression
- acute heart failure
- oxidative stress
- single cell
- genome wide
- rna seq
- risk factors
- coronary artery disease
- dna methylation
- protein protein
- insulin resistance
- wound healing
- metabolic syndrome
- skeletal muscle
- weight loss