Adipose-Derived Regenerative Cell Transplantation for the Treatment of Hand Dysfunction in Systemic Sclerosis: A Randomized Clinical Trial.
Zsuzsanna H McMahanPaul CaldronRichard W MartinSuzanne KafajaRobert F SpieraShadi ShahouriAnkoor ShahVivien HsuJohn ErvinRobert W SimmsRobyn T DomsicVirginia SteenLaura K HummersChris DerkMaureen D MayesSoumya ChatterjeeJohn VargaSteven KestenJohn K FraserDaniel E FurstPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
While the primary end point of this trial was not achieved, efficacy trends were observed in patients with dcSSc. Adipose tissue harvest and ADRC injection were demonstrated to be feasible. Further clinical trials of this intervention in the setting of dcSSc are warranted.
Keyphrases
- systemic sclerosis
- clinical trial
- cell therapy
- interstitial lung disease
- adipose tissue
- stem cells
- phase ii
- randomized controlled trial
- phase iii
- mesenchymal stem cells
- study protocol
- single cell
- insulin resistance
- high fat diet
- open label
- metabolic syndrome
- ultrasound guided
- bone marrow
- type diabetes
- rheumatoid arthritis
- combination therapy
- idiopathic pulmonary fibrosis