Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.
Hua YuFen QuBin ShanBin HuangWei JiaCha ChenAiqing LiMinhui MiaoXin ZhangChunmei BaoYunmin XuKalyan D ChavdaYi-Wei TangBarry N KreiswirthHong DuLiang ChenPublished in: Antimicrobial agents and chemotherapy (2016)
The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.
Keyphrases
- escherichia coli
- klebsiella pneumoniae
- global health
- multidrug resistant
- biofilm formation
- copy number
- end stage renal disease
- healthcare
- ejection fraction
- genome wide
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- urinary tract infection
- dna methylation
- cystic fibrosis
- patient reported outcomes
- crispr cas
- candida albicans
- staphylococcus aureus
- real time pcr
- bioinformatics analysis