A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis.

Eunice K PoonLigong LiuKai-Chen Wu Junxian Lim Matthew J SweetRink-Jan LohmanAbishek IyerDavid P Fairlie

Published in: British journal of pharmacology (2024)

A novel inhibitor of class IIa HDACs has been shown to have an anti-inflammatory and anti-arthritic profile distinct from current therapies. It is efficacious in reducing macrophage infiltration and joint inflammation in a chronic model of rat arthritis.

Keyphrases

oxidative stress
rheumatoid arthritis
anti inflammatory
diabetic rats
high glucose
dna methylation
drug induced
adipose tissue
gene expression
endothelial cells
wound healing
tissue engineering