Prognostic implications, genomic and immune characteristics of lung adenocarcinoma with lepidic growth pattern.

Yue LiDonglai ChenYi XuQifeng DingXuejun XuYongzhong LiYedong MiYongbing Chen

Published in: Journal of clinical pathology (2024)

LP+A was a unique histological subtype with a higher EGFR mutation rate, lower tumour mutation burden and immune checkpoint expression levels. Our findings suggested potential benefits from targeted therapy over immunotherapy in LP+A.

Keyphrases

small cell lung cancer
poor prognosis
epidermal growth factor receptor
tyrosine kinase
copy number
risk factors
gene expression
human health
dna methylation
risk assessment
climate change
genome wide