Long noncoding RNA SNHG12 suppresses esophageal squamous cell carcinoma progression through competing endogenous RNA networks.

Mingqiang LiangZ PanF YuC Chen

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)

This is the first study to reveal that SNHG12 is downregulated in ESCC tissues and could be used as a prognostic tool. SNHG12 suppressed tumor progression in ESCC cells, serving as a potential biomarker. The SNHG12/miRNA-195-5p/BCL9 network is proposed to be the mechanism leading to ESCC progression.

Keyphrases

poor prognosis
long noncoding rna
long non coding rna
induced apoptosis
gene expression
signaling pathway
cell cycle arrest
genome wide
oxidative stress
endoplasmic reticulum stress
pi k akt
network analysis