The Protective Effect of Kolaviron on Molecular, Cellular, and Behavioral Characterization of Cerebellum in the Rat Model of Demyelinating Diseases.

Gabriel Olaiya Omotoso Leviticus Oghenevurinrin Arietarhire Ileje Inelo Ukwubile Gbadamosi Ismail Temitayo

Published in: Basic and clinical neuroscience (2020)

CPZ treatment significantly depressed locomotor and exploratory activities. Furthermore, it increased OS and cerebellar toxicity. However, KV intervention significantly enhanced behavioral functions and ameliorated CPZ-induced cerebellar degeneration. Moreover, it considerably regulated OS markers in the cerebellum of the rat model of demyelinating diseases.

Keyphrases

randomized controlled trial
spinal cord injury
oxidative stress
high glucose
diabetic rats
transcription factor
magnetic resonance imaging
drug induced
single molecule
combination therapy
endothelial cells