Airway regulatory T cells are decreased in COPD with a rapid decline in lung function.
Jonas Eriksson-StrömJamshid PourazarRobert LinderAnders BlombergAnne LindbergAnders BuchtAnnelie F BehndigPublished in: Respiratory research (2020)
COPD subjects with a rapid decline in lung function had lower proportions of T cells with regulatory function in BAL fluid, suggesting that an inability to suppress the inflammatory response following smoking might lead to a more rapid decline in FEV1. Trial registration Clinicaltrials.gov identifier NCT02729220.
Keyphrases
- lung function
- regulatory t cells
- chronic obstructive pulmonary disease
- cystic fibrosis
- air pollution
- inflammatory response
- loop mediated isothermal amplification
- dendritic cells
- clinical trial
- transcription factor
- study protocol
- randomized controlled trial
- smoking cessation
- phase iii
- lps induced
- sensitive detection
- open label