Alkanes in Minisci-Type Reaction under Photocatalytic Conditions with Hydrogen Evolution.
Loris LazeBeatriz Quevedo-FloresIrene BosqueJose C Gonzalez-GomezPublished in: Organic letters (2023)
We report herein a protocol for the selective activation of C( sp 3 )-H bonds based on the interplay of two readily available organic catalysts and their successful implementation in cross-coupling azaarenes with alkanes. This Minisci-like reaction is promoted by visible light at room temperature and is free from chemical oxidants, metals, and chlorinated solvents. A wide range of substrates are compatible, including some bioactive molecules. Mechanistic studies support a dual catalytic cycle with H 2 evolution.
Keyphrases
- visible light
- room temperature
- ionic liquid
- randomized controlled trial
- primary care
- healthcare
- highly efficient
- quality improvement
- case control
- electron transfer
- health risk
- health risk assessment
- crystal structure
- polycyclic aromatic hydrocarbons
- gas chromatography
- climate change
- water soluble
- reduced graphene oxide
- gold nanoparticles
- high resolution
- tandem mass spectrometry