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Alkanes in Minisci-Type Reaction under Photocatalytic Conditions with Hydrogen Evolution.

Loris LazeBeatriz Quevedo-FloresIrene BosqueJose C Gonzalez-Gomez
Published in: Organic letters (2023)
We report herein a protocol for the selective activation of C( sp 3 )-H bonds based on the interplay of two readily available organic catalysts and their successful implementation in cross-coupling azaarenes with alkanes. This Minisci-like reaction is promoted by visible light at room temperature and is free from chemical oxidants, metals, and chlorinated solvents. A wide range of substrates are compatible, including some bioactive molecules. Mechanistic studies support a dual catalytic cycle with H 2 evolution.
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