Phosphodiesterase 11 A (PDE11A), a potential biomarker for glioblastoma.
Hyunji LeeSungjin ParkGyeyeong KongSo Hee KwonJisoo ParkJongsun ParkSeon-Hwan KimPublished in: Toxicological research (2022)
Phosphodiesterase 11A (PDE11A), a 3',5'-cyclic nucleotide phosphodiesterase, is a key regulator of intracellular signaling that functions by degrading cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). However, the function of PDE11A in brain tumors is currently unclear. In this study, we found that PDE11A may be involved in glioblastoma development. The protein and mRNA levels of PDE11A were significantly higher in U87-MG, U251-MG and U343-MG glioblastoma cell lines. Gene expression analyses by deep-sequencing revealed that PDE11A mRNA levels were higher in U87-MG and U251-MG cells compared to other cells in the cerebral cortex. A comprehensive analysis of The Cancer Genome Atlas (TCGA) data revealed that PDE11A expression was also elevated in glioblastoma patients. Taken together, these data indicate that PDE11A expression was increased in glioblastoma cell lines and glioma patients, suggesting that PDE11A could be a putative diagnostic marker and therapeutic target for glioma.
Keyphrases
- end stage renal disease
- gene expression
- binding protein
- induced apoptosis
- ejection fraction
- single cell
- newly diagnosed
- chronic kidney disease
- poor prognosis
- prognostic factors
- cell cycle arrest
- dna methylation
- peritoneal dialysis
- machine learning
- squamous cell carcinoma
- signaling pathway
- electronic health record
- nitric oxide
- patient reported outcomes
- big data
- young adults
- small molecule
- cell proliferation
- endoplasmic reticulum stress
- genome wide
- amino acid