(2 + 2 + 1)-Cyclization of Glycine Derivatives with Alkenes and CO 2 .

Published in: Organic letters (2024)

A highly atom-economic (2 + 2 + 1)-cyclization of glycine derivatives with alkenes and CO 2 facilitated by visible light catalysis is described. A range of multisubstituted pyrrolidones were synthesized under simple and mild reaction conditions. A reasonable mechanism involving redox-neutral radical-polar crossover is proposed.

Keyphrases

visible light
electron transfer
structure activity relationship
molecular dynamics
open label
randomized controlled trial
ionic liquid
clinical trial
life cycle