IL-1β prevents ILC2 expansion, type 2 cytokine secretion, and mucus metaplasia in response to early-life rhinovirus infection in mice.
Mingyuan HanTomoko IshikawaJennifer R BermickCharu RajputJing LeiAdam M GoldsmithCaitlin R JarmanJulie LeeJ Kelley BentleyMarc B HershensonPublished in: Allergy (2020)
Macrophage IL-1β limits type 2 inflammation and mucous metaplasia following RV infection by suppressing epithelial cell innate cytokine expression. Reduced IL-1β production in immature animals provides a mechanism permitting asthma development after early-life viral infection.