Roots of Astragalus propinquus Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury.

Juan Chen Donglai Ma Jun Bao Ying Zhang Guoxing Deng

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

RAP stimulation inhibited ferroptosis by regulating the expression of the key ferroptosis factors XCT, SLC3A2, GPX4, NRF2, HO-1, and IREB2. In conclusion, RAP regulates transmembrane iron transport and ferroptosis to improve CIRI.

Keyphrases

cell death
ischemia reperfusion injury
oxidative stress
poor prognosis
subarachnoid hemorrhage
iron deficiency
signaling pathway
cell proliferation
brain injury