Broad next generation integrated sequencing of myelofibrosis identifies disease-specific and age-related genomic alterations.

Malathi Kandarpa Dan R Robinson Yi-Mi Wu Tingting Qin Kristen Pettit Qing Li Gary D Luker Maureen A Sartor Arul M Chinnaiyan Moshe Talpaz

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our results illustrate that evolution of MF from ET/PV/PrePMF likely advances with age, accumulation of mutations, and activation of proliferative pathways. The genes and pathways identified by integrated genomics approach provide insight into disease transformation and progression, and potential targets for therapeutic intervention.

Keyphrases

genome wide
single cell
randomized controlled trial
copy number
gene expression