HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples.
Eleonora LoiCesare ZavattariAlessandro TommasiLoredana MoiMatteo CanaleAgnese PoClaudia SabatoAna Florencia Vega-BenedettiPina ZiranuMarco PuzzoniEleonora LaiLuca FaloppiMaría RullánJuan CarrascosaIrene AmatJesús M UrmanMaria ArechederraCarmen BerasainElisabetta FerrettiStefano CascinuMatias A AvilaSergio AlonsoMario ScartozziPatrizia ZavattariPublished in: British journal of cancer (2022)
We identified a novel fully efficient BTC biomarker, associated with HOXD8 gene, detectable both in tissue and bile by a standardised assay ready-to-use in clinical trials also including samples from non-invasive matrices.