Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma.

E Georg LuebeckKit CurtiusWilliam D HazeltonSean MadenMing YuPrashanthi N ThotaDeepa T PatilAmitabh ChakJoseph E WillisWilliam M Grady

Published in: Clinical epigenetics (2017)

Taken together, our findings suggest that epigenetic drift evolution acts to significantly reduce the expression of developmental genes that may alter tissue characteristics and improve functional adaptation during BE to EAC progression.

Keyphrases

dna methylation
bioinformatics analysis
gene expression
genome wide
poor prognosis
squamous cell carcinoma
locally advanced
binding protein
genome wide identification
radiation therapy
long non coding rna
rectal cancer