MOFs-based Magnetic Nanozyme to Boost Cascade ROS Accumulation for Augmented Tumor Ferroptosis.
Ying YuanBo ChenXingxing AnZhanhang GuoXin LiuHao LuFangxin HuZhigang ChenChunxian GuoChang Ming LiPublished in: Advanced healthcare materials (2024)
The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. We report here a MOFs-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid (HA), delivering excellent magneto-photonic response for efficient ferroptosis. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase (OXD)-like catalysis to generate O 2 - , which is converted to H 2 O 2 by superoxide dismutase-like activity and subsequent ·OH by magneto-promoted peroxidase (POD) behavior. Newly formed Fe-N coordination and increased Fe 2+ /Fe 3+ levels in the PZFH contribute to the enhanced POD activity, which is further enhanced by accelerated surface electron transfer when exposure to alternated magnetic field. Accumulation of lipid peroxides is eventually accomplished through the conversion of ·OH radicals and singlet oxygen ( 1 O 2 ) produced through laser irradiation. When combined with the depletion of inhibition of glutathione and glutathione peroxidase 4, PZFH exhibits significantly enhanced ferroptosis in tumor-bearing mice, offering insights into nanomedicine for ferroptosis and holding great promise in clinical antitumor therapies. This article is protected by copyright. All rights reserved.
Keyphrases
- cell death
- metal organic framework
- hyaluronic acid
- cell cycle arrest
- electron transfer
- hydrogen peroxide
- working memory
- molecularly imprinted
- type diabetes
- cell proliferation
- dna damage
- photodynamic therapy
- fatty acid
- aqueous solution
- pet imaging
- radiation therapy
- metabolic syndrome
- machine learning
- cancer therapy
- insulin resistance
- adipose tissue
- mass spectrometry
- signaling pathway
- single molecule
- positron emission tomography
- simultaneous determination
- wild type
- pi k akt