Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps irrespective of gender: results from the SINUS-52 trial.

Wytske J FokkensClaus BachertClaire HopkinsOsama MarglaniAmy PraestgaardScott NashYamo DenizPaul J RoweHarry SacksJuby A Jacob-Nara

Published in: Clinical & translational immunology (2024)

Female patients had greater asthma, NSAID-ERD and HRQoL burden at baseline than male patients. Dupilumab treatment significantly improved objective and subjective outcomes compared with placebo, irrespective of gender.

Keyphrases

end stage renal disease
chronic rhinosinusitis
ejection fraction
newly diagnosed
chronic kidney disease
clinical trial
chronic obstructive pulmonary disease
peritoneal dialysis
randomized controlled trial
physical activity
study protocol
skeletal muscle
depressive symptoms
lung function
placebo controlled