Applications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy.
Daniel V AraujoAo WangDax TortiAlberto LeonKayla MarshAoife McCarthyHal K BermanAnna SpreaficoAaron R HansenAlbiruni-Abdul RazakPhilippe L BedardLisa WangEric PlackmannHelen ChowHua BaoXue WuTrevor J PughLillian L SiuPublished in: JNCI cancer spectrum (2021)
In this small series, bTMB correlated with tTMB. An on-treatment decrease in VAF of mutations detected in ctDNA at baseline was observed in responders. Larger studies to verify our findings are warranted.