Trevor J Pugh (Trevor Pugh)

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 91

Top Topics

Gene Expression

Circulating Tumor

Top Venues

Nature communications

Clinical cancer research : an official journal of the American Association for Cancer Research

Cancer discovery

JCO precision oncology

This page only lists publications with an associated author ORCID identifier.

Publications

Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. Cancer discovery 14 (6) (2024)
Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. Cancer discovery 14 (6) (2024)
Jie Li, Christopher R Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martín A Rivas, Oliver Weigert, Trevor J Pugh, Amy Chadburn, Christian Steidl, David W Scott, Robert G Roeder, Christopher E Mason, Roberta Zappasodi, Wendy Béguelin, Ari M Melnick
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications 15 (1) (2024)
Jelena Lukovic, Melania Pintilie, Kathy Han, Anthony W Fyles, Jeffrey P Bruce, Rene Quevedo, Trevor J Pugh, Christina S Fjeldbo, Heidi Lyng, Michael F Milosevic
An immune gene expression risk score for distant metastases after radiotherapy for cervical cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors. Cancer discovery 14 (6) (2024)
Jie Li, Christopher R Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martín A Rivas, Oliver Weigert, Trevor J Pugh, Amy Chadburn, Christian Steidl, David W Scott, Robert G Roeder, Christopher E Mason, Roberta Zappasodi, Wendy Béguelin, Ari M Melnick
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications 15 (1) (2024)
Jie Li, Christopher R Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martín A Rivas, Oliver Weigert, Trevor J Pugh, Amy Chadburn, Christian Steidl, David W Scott, Robert G Roeder, Christopher E Mason, Roberta Zappasodi, Wendy Béguelin, Ari M Melnick
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications 15 (1) (2024)
Jie Li, Christopher R Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martín A Rivas, Oliver Weigert, Trevor J Pugh, Amy Chadburn, Christian Steidl, David W Scott, Robert G Roeder, Christopher E Mason, Roberta Zappasodi, Wendy Béguelin, Ari M Melnick
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications 15 (1) (2024)
Scott C Lien, Dalam Ly, S Y Cindy Yang, Ben X Wang, Derek L Clouthier, Michael St Paul, Ramy Gadalla, Babak Noamani, Carlos R Garcia-Batres, Sarah Boross-Harmer, Philippe L Bedard, Trevor J Pugh, Anna Spreafico, Naoto Hirano, Albiruni R A Razak, Pamela S Ohashi
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient. Nature communications 15 (1) (2024)
Philip Barbulescu, Chetan K Chana, Matthew K Wong, Ines Ben Makhlouf, Jeffrey P Bruce, Yuqing Feng, Alexander F A Keszei, Cassandra Wong, Rukshana Mohamad-Ramshan, Laura C McGary, Mohammad A Kashem, Derek F Ceccarelli, Stephen Orlicky, Yifei Fang, Huihui Kuang, Mohammad Mazhab-Jafari, Rossanna C Pezo, Ashok S Bhagwat, Trevor J Pugh, Anne-Claude Gingras, Frank Sicheri, Rossanna C Pezo
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation. Nature communications 15 (1) (2024)
Derek Wong, Maha Tageldein, Ping Luo, Erik Ensminger, Jeffrey Bruce, Leslie Oldfield, Haifan Gong, Nicholas William Fischer, Brianne Laverty, Vallijah Subasri, Scott Davidson, Reem Khan, Anita Villani, Adam Shlien, Raymond H Kim, David Malkin, Trevor J Pugh
Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns. Nature communications 15 (1) (2024)
Alberto Hernando-Calvo, S Y Cindy Yang, Maria Vila-Casadesús, Ming Han, Zhihui Amy Liu, A Hal K Berman, Anna Spreafico, Albiruni Abdul Razak, Stéphanie Lheureux, Aaron Richard Hansen, Deborah Lo Giacco, Farnoosh Abbas-Aghababazadeh, Judith Matito, Benjamin Haibe-Kains, Trevor J Pugh, Scott V Bratman, Meenakshi Malhotra, Roger Berche, Omar Saavedra, Elena Garralda, Sawako Elston, Lillian L Siu, Pamela S Ohashi, Ana Vivancos, Philippe L Bedard
Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab. JCO precision oncology 8 (2024)
Scott C Lien, Dalam Ly, S Y Cindy Yang, Ben X Wang, Derek L Clouthier, Michael St Paul, Ramy Gadalla, Babak Noamani, Carlos R Garcia-Batres, Sarah Boross-Harmer, Philippe L Bedard, Trevor J Pugh, Anna Spreafico, Naoto Hirano, Albiruni R A Razak, Pamela S Ohashi
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient. Nature communications 15 (1) (2024)
Derek Wong, Maha Tageldein, Ping Luo, Erik Ensminger, Jeffrey Bruce, Leslie Oldfield, Haifan Gong, Nicholas William Fischer, Brianne Laverty, Vallijah Subasri, Scott Davidson, Reem Khan, Anita Villani, Adam Shlien, Raymond H Kim, David Malkin, Trevor J Pugh
Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns. Nature communications 15 (1) (2024)
Alberto Hernando-Calvo, S Y Cindy Yang, Maria Vila-Casadesús, Ming Han, Zhihui Amy Liu, A Hal K Berman, Anna Spreafico, Albiruni Abdul Razak, Stéphanie Lheureux, Aaron Richard Hansen, Deborah Lo Giacco, Farnoosh Abbas-Aghababazadeh, Judith Matito, Benjamin Haibe-Kains, Trevor J Pugh, Scott V Bratman, Meenakshi Malhotra, Roger Berche, Omar Saavedra, Elena Garralda, Sawako Elston, Lillian L Siu, Pamela S Ohashi, Ana Vivancos, Philippe L Bedard
Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab. JCO precision oncology 8 (2024)
Jie Li, Christopher R Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martín A Rivas, Oliver Weigert, Trevor J Pugh, Amy Chadburn, Christian Steidl, David W Scott, Robert G Roeder, Christopher E Mason, Roberta Zappasodi, Wendy Béguelin, Ari M Melnick
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications 15 (1) (2024)
Eric Y Zhao, Enrique Sanz-Garcia, Zhihui Amy Liu, Derek Wong, Kayla Marsh, Albiruni Abdul Razak, Anna Spreafico, Philippe L Bedard, Aaron Richard Hansen, Stéphanie Lheureux, Dax Torti, Bernard Lam, Shih Yu Cindy Yang, Justin M Burgener, Ping Luo, Yong Zeng, Nicholas Cheng, Phillip Awadalla, Scott V Bratman, Pamela S Ohashi, Trevor J Pugh, Lillian L Siu
Early changes in tumor-naive cell-free methylomes and fragmentomes predict outcomes in pembrolizumab-treated solid tumors. Cancer discovery (2024)
Jie Li, Christopher R Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martín A Rivas, Oliver Weigert, Trevor J Pugh, Amy Chadburn, Christian Steidl, David W Scott, Robert G Roeder, Christopher E Mason, Roberta Zappasodi, Wendy Béguelin, Ari M Melnick
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications 15 (1) (2024)
Scott C Lien, Dalam Ly, S Y Cindy Yang, Ben X Wang, Derek L Clouthier, Michael St Paul, Ramy Gadalla, Babak Noamani, Carlos R Garcia-Batres, Sarah Boross-Harmer, Philippe L Bedard, Trevor J Pugh, Anna Spreafico, Naoto Hirano, Albiruni R A Razak, Pamela S Ohashi
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient. Nature communications 15 (1) (2024)
Derek Wong, Maha Tageldein, Ping Luo, Erik Ensminger, Jeffrey Bruce, Leslie Oldfield, Haifan Gong, Nicholas William Fischer, Brianne Laverty, Vallijah Subasri, Scott Davidson, Reem Khan, Anita Villani, Adam Shlien, Raymond H Kim, David Malkin, Trevor J Pugh
Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns. Nature communications 15 (1) (2024)
Jelena Lukovic, Melania Pintilie, Kathy Han, Anthony W Fyles, Jeffrey P Bruce, Rene Quevedo, Trevor J Pugh, Christina S Fjeldbo, Heidi Lyng, Michael F Milosevic
An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (6) (2024)
Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J Pugh, Carl Virtanen, Jason Moffat, Reidar A Grénman, Marianne Koritzinsky, Bradly G Wouters
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer. Communications biology 6 (1) (2023)
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie D Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Molecular Genetic Characteristics of FANCI , a Proposed New Ovarian Cancer Predisposing Gene. Genes 14 (2) (2023)
Vallijah Subasri, Nicholas Light, Nisha Kanwar, Jack J Brzezinski, Ping Luo, Jordan R Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L Finlay, Kim E Nichols, Noa Alon, Ledia Brunga, Jo Anson, Wendy K Kohlmann, Kelvin César de Andrade, Payal P Khincha, Sharon A Savage, Joshua D Schiffman, Rosanna Weksberg, Trevor J Pugh, Anita Villani, Adam Shlien, Anna Goldenberg, David Malkin
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome. Cancer research communications 3 (5) (2023)
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie D Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Molecular Genetic Characteristics of FANCI , a Proposed New Ovarian Cancer Predisposing Gene. Genes 14 (2) (2023)
Danielle C Croucher, Anup Joseph Devasia, Dor D Abelman, Ali Mahdipour-Shirayeh, Zhihua Li, Natalie Erdmann, Rodger E Tiedemann, Trevor J Pugh, Suzanne Trudel
Single-cell profiling of multiple myeloma reveals molecular response to FGFR3 inhibitor despite clinical progression. Cold Spring Harbor molecular case studies (2023)
Derek Wong, Ping Luo, Leslie E Oldfield, Haifan Gong, Ledia Brunga, Ron Rabinowicz, Vallijah Subasri, Clarissa Chan, Tiana Downs, Kirsten M Farncombe, Beatrice Luu, Maia Leigh Norman, Julia A Sobotka, Precious Uju, Jenna Eagles, Stephanie Pedersen, Johanna Wellum, Arnavaz Danesh, Stephenie D Prokopec, Eric Y Zhao, Nadia Znassi, Lawrence E Heisler, Richard Jovelin, Bernard Lam, Beatriz E Lujan-Toro, Kayla Marsh, Yogi Sundaravadanam, Dax Torti, Carina Man, Anna Goldenberg, Wei Xu, Patrick Veit-Haibach, Andrea Schwarz Doria, David Malkin, Raymond H Kim, Trevor J Pugh
Early Cancer Detection in Li-Fraumeni Syndrome with Cell-Free DNA. Cancer discovery (2023)
Vallijah Subasri, Nicholas Light, Nisha Kanwar, Jack J Brzezinski, Ping Luo, Jordan R Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L Finlay, Kim E Nichols, Noa Alon, Ledia Brunga, Jo Anson, Wendy K Kohlmann, Kelvin César de Andrade, Payal P Khincha, Sharon A Savage, Joshua D Schiffman, Rosanna Weksberg, Trevor J Pugh, Anita Villani, Adam Shlien, Anna Goldenberg, David Malkin
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome. Cancer research communications 3 (5) (2023)
Suganth Suppiah, Sheila Mansouri, Yasin Mamatjan, Jeffrey C Liu, Minu M Bhunia, Vikas Patil, Prisni Rath, Bharati Mehani, Pardeep Heir, Severa Bunda, German L Velez-Reyes, Olivia Singh, Nazanin Ijad, Neda Pirouzmand, Tatyana Dalcourt, Ying Meng, Shirin Karimi, Qingxia Wei, Farshad Nassiri, Trevor J Pugh, Gary D Baider, Kenneth D Aldape, David A Largaespada, Gelareh Zadeh
Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities. Nature communications 14 (1) (2023)
Anirban Das, Uri Tabori, Lauren C Sambira Nahum, Natalie B Collins, Rebecca J Deyell, Rina Dvir, Cecile Faure Conter, Timothy Eg Hassall, Jane E Minturn, Melissa Edwards, Elissa Brookes, Vanessa Bianchi, Adrian B Levine, Simone Cardozo Stone, Sumedha Sudhaman, Santiago Sánchez-Ramírez, Ayse Bahar Ercan, Lucie K Stengs, Jiil Chung, Logine Negm, Gad A Getz, Yosef E Maruvka, Birgit Betina Ertl-Wagner, Pamela S Ohashi, Trevor J Pugh, Cynthia Hawkins, Eric Bouffet, Daniel A Morgenstern
Efficacy of nivolumab in pediatric cancers with high mutation burden and mismatch-repair deficiency. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Derek Wong, Ping Luo, Nadia Znassi, Diana Paola Arteaga Ceballos, Diana Gray, Arnavaz Danesh, Ming Han, Eric Y Zhao, Stephanie Pedersen, Stephenie D Prokopec, Yogi Sundaravadanam, Dax Torti, Kayla Marsh, Sareh Keshavarzi, Wei Xu, Hatem Krema, Anthony M Joshua, Marcus O Butler, Trevor J Pugh
Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma. Cancer research communications 3 (2) (2023)
Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J Pugh, Carl Virtanen, Jason Moffat, Reidar A Grénman, Marianne Koritzinsky, Bradly G Wouters
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer. Communications biology 6 (1) (2023)
Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J Pugh, Carl Virtanen, Jason Moffat, Reidar A Grénman, Marianne Koritzinsky, Bradly G Wouters
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer. Communications biology 6 (1) (2023)
Suganth Suppiah, Sheila Mansouri, Yasin Mamatjan, Jeffrey C Liu, Minu M Bhunia, Vikas Patil, Prisni Rath, Bharati Mehani, Pardeep Heir, Severa Bunda, German L Velez-Reyes, Olivia Singh, Nazanin Ijad, Neda Pirouzmand, Tatyana Dalcourt, Ying Meng, Shirin Karimi, Qingxia Wei, Farshad Nassiri, Trevor J Pugh, Gary D Baider, Kenneth D Aldape, David A Largaespada, Gelareh Zadeh
Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities. Nature communications 14 (1) (2023)
Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J Pugh, Carl Virtanen, Jason Moffat, Reidar A Grénman, Marianne Koritzinsky, Bradly G Wouters
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer. Communications biology 6 (1) (2023)
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie D Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Molecular Genetic Characteristics of FANCI , a Proposed New Ovarian Cancer Predisposing Gene. Genes 14 (2) (2023)
Derek Wong, Ping Luo, Nadia Znassi, Diana Paola Arteaga Ceballos, Diana Gray, Arnavaz Danesh, Ming Han, Eric Y Zhao, Stephanie Pedersen, Stephenie D Prokopec, Yogi Sundaravadanam, Dax Torti, Kayla Marsh, Sareh Keshavarzi, Wei Xu, Hatem Krema, Anthony M Joshua, Marcus O Butler, Trevor J Pugh
Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma. Cancer research communications 3 (2) (2023)
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie D Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Molecular Genetic Characteristics of FANCI , a Proposed New Ovarian Cancer Predisposing Gene. Genes 14 (2) (2023)
Vallijah Subasri, Nicholas Light, Nisha Kanwar, Jack J Brzezinski, Ping Luo, Jordan R Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L Finlay, Kim E Nichols, Noa Alon, Ledia Brunga, Jo Anson, Wendy K Kohlmann, Kelvin César de Andrade, Payal P Khincha, Sharon A Savage, Joshua D Schiffman, Rosanna Weksberg, Trevor J Pugh, Anita Villani, Adam Shlien, Anna Goldenberg, David Malkin
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome. Cancer research communications 3 (5) (2023)
Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A Oldridge, Sumedha Sudhaman, Kelsey Zhu, S Y Cindy Yang, David T Mulder, Jeffrey P Bruce, Joseph N Paulson, Pichai Raman, Yuankun Zhu, Adam C Resnick, Poul H Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D Johann, Marcel Kool, David T W Jones, Stefan M Pfister, Natalie Jäger, Trevor J Pugh
Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours. Genome medicine 15 (1) (2023)
Vallijah Subasri, Nicholas Light, Nisha Kanwar, Jack J Brzezinski, Ping Luo, Jordan R Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L Finlay, Kim E Nichols, Noa Alon, Ledia Brunga, Jo Anson, Wendy K Kohlmann, Kelvin César de Andrade, Payal P Khincha, Sharon A Savage, Joshua D Schiffman, Rosanna Weksberg, Trevor J Pugh, Anita Villani, Adam Shlien, Anna Goldenberg, David Malkin
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome. Cancer research communications 3 (5) (2023)
Vallijah Subasri, Nicholas Light, Nisha Kanwar, Jack J Brzezinski, Ping Luo, Jordan R Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L Finlay, Kim E Nichols, Noa Alon, Ledia Brunga, Jo Anson, Wendy K Kohlmann, Kelvin César de Andrade, Payal P Khincha, Sharon A Savage, Joshua D Schiffman, Rosanna Weksberg, Trevor J Pugh, Anita Villani, Adam Shlien, Anna Goldenberg, David Malkin
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome. Cancer research communications 3 (5) (2023)
Anirban Das, Nicholas R Fernandez, Adrian B Levine, Vanessa Bianchi, Lucie K Stengs, Jiil Chung, Logine Negm, Jose Rafael Dimayacyac, Yuan Chang, Liana Nobre, Ayse Bahar Ercan, Santiago Sánchez-Ramírez, Sumedha Sudhaman, Melissa Edwards, Larouche Valérie, David Samuel, An Van Damme, David Gass, David S Ziegler, Stefan S Bielack, Carl J Koschmann, Shayna Zelcer, Michal Yalon-Oren, Gadi Abede Campino, Tomasz Sarosiek, Kim E Nichols, Rebecca Loret De Mola, Kevin Bielamowicz, Magnus Sabel, Charlotta A Frojd, Matthew D Wood, Jason M Glover, Yi-Yen Lee, Magimairajan Issai Vanan, Jenny K Adamski, Sébastien Perreault, Omar Chamdine, Magnus Aassved Hjort, Michal Zápotocký, Fernando Carceller, Erin Wright, Ivana Fedorakova, Alexander Lossos, Ryuma Tanaka, Michael Philip Osborn, Deborah T Blumenthal, Melyssa Aronson, Ute Bartels, Annie Huang, Vijay Ramsawami, David Malkin, Adam Shlien, Anita Villani, Peter B Dirks, Trevor J Pugh, Gad A Getz, Yosef E Maruvka, Derek S Tsang, Birgit Betina Ertl-Wagner, Cynthia Hawkins, Eric Bouffet, Daniel A Morgenstern, Uri Tabori
Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: A report from the International RRD Consortium. Cancer discovery (2023)
Suganth Suppiah, Sheila Mansouri, Yasin Mamatjan, Jeffrey C Liu, Minu M Bhunia, Vikas Patil, Prisni Rath, Bharati Mehani, Pardeep Heir, Severa Bunda, German L Velez-Reyes, Olivia Singh, Nazanin Ijad, Neda Pirouzmand, Tatyana Dalcourt, Ying Meng, Shirin Karimi, Qingxia Wei, Farshad Nassiri, Trevor J Pugh, Gary D Baider, Kenneth D Aldape, David A Largaespada, Gelareh Zadeh
Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities. Nature communications 14 (1) (2023)
Ino De Bruijn, Ritika Kundra, Brooke Mastrogiacomo, Thinh Ngoc Tran, Luke Sikina, Tali Mazor, Xiang Li, Angelica Ochoa, Gaofei Zhao, Bryan Lai, Adam Abeshouse, Diana Baiceanu, Ersin Ciftci, Ugur Dogrusoz, Andrew Dufilie, Ziya Erkoc, Elena G Lara, Zhaoyuan Fu, Benjamin E Gross, Charles D Haynes, Allison P Heath, David M Higgins, Prasanna Jagannathan, Karthik Kalletla, Priti Kumari, James R Lindsay, Aaron Lisman, Bas Leenknegt, Pieter Lukasse, Divya Madala, Ramyasree Madupuri, Pim van Nierop, Oleguer Plantalech, Joyce Quach, Adam C Resnick, Sander Y A Rodenburg, Baby A Satravada, Fedde Schaeffer, Robert Sheridan, Jessica Singh, Rajat Sirohi, Selcuk Onur Sumer, Sjoerd van Hagen, Avery Wang, Manda Wilson, Hongxin Zhang, Kelsey Zhu, Nicole Rusk, Samantha Brown, Jessica A Lavery, Katherine S Panageas, Julia E Rudolph, Michele L LeNoue-Newton, Jeremy L Warner, Xindi Guo, Haley Hunter-Zinck, Thomas V Yu, Shirin Pillai, Chelsea Nichols, Stuart M Gardos, John Philip, Genie Bpc Core Team, Aacr Project Genie Consortium, Kenneth L Kehl, Gregory J Riely, Deborah Schrag, Jocelyn Lee, Michael V Fiandalo, Shawn M Sweeney, Trevor J Pugh, Chris Sander, Ethan Cerami, Jianjiong Gao, Nikolaus Schultz
Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal. Cancer research (2023)
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie D Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Molecular Genetic Characteristics of FANCI , a Proposed New Ovarian Cancer Predisposing Gene. Genes 14 (2) (2023)
Arash Nabbi, Arnavaz Danesh, Osvaldo Espin-Garcia, Stephanie Pedersen, Johanna Wellum, Lingyan Helen Fu, Joseph N Paulson, Didier Frappaz, Lynley V Marshall, Tanya Trippett, Gianluca Rossato, Trevor J Pugh, Katherine E Hutchinson
Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab. Nature cancer (2023)
Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Natalie Stickle, Christine Beswick, Zvi Shalev, Stefano Marastoni, Soroush Samadian, Anna Dvorkin-Gheva, Azin Sayad, Mikhail Bashkurov, Pedro Boasquevisque, Alessandro Datti, Trevor J Pugh, Carl Virtanen, Jason Moffat, Reidar A Grénman, Marianne Koritzinsky, Bradly G Wouters
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer. Communications biology 6 (1) (2023)
Stéphanie Lheureux, Stephenie D Prokopec, Leslie E Oldfield, Eduardo Gonzalez-Ochoa, Jeffrey P Bruce, Derek Wong, Arnavaz Danesh, Dax Torti, Jonathan Torchia, Alexander Fortuna, Sharanjit Singh, Matthew Irving, Kayla Marsh, Bernard Lam, Vanessa Speers, Aleksandra Yosifova, Ana Oaknin, Ainhoa Madariaga, Neesha C Dhani, Valerie Bowering, Amit M Oza, Trevor J Pugh
Identifying mechanisms of resistance by circulating tumour DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at time of PARP Inhibitor Progression. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G Mullighan, Reinhard Buttner, Trevor J Pugh, Sean M Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, Vaidehi Jobanputra
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO precision oncology 6 (2022)
Trevor J Pugh, Jonathan L Bell, Jeffrey P Bruce, Gary J Doherty, Matthew R Galvin, Michelle F Green, Haley Hunter-Zinck, Priti Kumari, Michele L LeNoue-Newton, Marilyn M Li, James R Lindsay, Tali Mazor, Andrea Ovalle, Stephen-John Sammut, Nikolaus Schultz, Thomas V Yu, Shawn M Sweeney, Brady Bernard, null null
AACR Project GENIE: 100,000 Cases and Beyond. Cancer discovery 12 (9) (2022)
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G Mullighan, Reinhard Buttner, Trevor J Pugh, Sean M Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, Vaidehi Jobanputra
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO precision oncology 6 (2022)
Jeff P Bruce, Ka-Fai To, Vivian Wai Yan Lui, Grace T Y Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y Yip, Brigette Buig Yue Ma, John K S Woo, Edwin Pun Hui, Michael K F Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y Y Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie D Prokopec, Man Wu, Johnny S H Kwan, Yuchen Liu, Jason Ying-Kuen Chan, C Andrew van Hasselt, Lawrence S Young, Christopher W Dawson, Ian Charles Paterson, Lee Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T C Chan, Trevor J Pugh, Kwok-Wai Lo
Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nature communications 13 (1) (2022)
Signy Chow, Olena Kis, David T Mulder, Arnavaz Danesh, Jeff Bruce, Ting Ting Wang, Donna Reece, Nizar Bhalis, Paola Neri, Peter J B Sabatini, Jonathan J Keats, Suzanne Trudel, Trevor J Pugh
Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing. Life science alliance 6 (1) (2022)
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G Mullighan, Reinhard Buttner, Trevor J Pugh, Sean M Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, Vaidehi Jobanputra
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO precision oncology 6 (2022)
Wei Shi, Mackenzie Fijardo, Jeffrey P Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B Y Hui, John Waldron, Trevor J Pugh, Kenneth W Yip, Fei-Fei Liu
CD8+ Tumor-Infiltrating Lymphocyte Abundance Is a Positive Prognostic Indicator in Nasopharyngeal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (23) (2022)
Brooke M Grant, Trevor J Pugh, Amit M Oza
Molecular monitoring in endometrial cancer - ready for prime time? Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G Mullighan, Reinhard Buttner, Trevor J Pugh, Sean M Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, Vaidehi Jobanputra
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO precision oncology 6 (2022)
Trevor J Pugh, Benjamin Haibe-Kains
REFLECTions on Combination Therapies Empowered by Data Sharing. Cancer discovery 12 (6) (2022)
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G Mullighan, Reinhard Buttner, Trevor J Pugh, Sean M Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Fröhling, Vaidehi Jobanputra
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO precision oncology 6 (2022)
Salma Shickh, Leslie E Oldfield, Marc Clausen, Chloe Mighton, Agnes Sebastian, Alessia Calvo, Nancy N Baxter, Lesa Dawson, Lynette S Penney, William Foulkes, Mark Basik, Sophie Sun, Kasmintan A Schrader, Dean A Regier, Aly Karsan, Aaron Pollett, Trevor J Pugh, Raymond H Kim, Yvonne Bombard, null null
"Game Changer": Health Professionals' Views on the Clinical Utility of Circulating Tumor DNA Testing in Hereditary Cancer Syndrome Management. The oncologist 27 (5) (2022)
Sujun Chen, Jessica Petricca, Wenbin Ye, Jiansheng Guan, Yong Zeng, Nicholas Cheng, Linsey Gong, Shu Yi Shen, Junjie T Hua, Megan Crumbaker, Michael Fraser, Stanley K Liu, Scott V Bratman, Theodorus H Van der Kwast, Trevor J Pugh, Anthony M Joshua, Daniel D De Carvalho, Kim N Chi, Phillip Awadalla, Guoli Ji, Felix Y Feng, Alexander W Wyatt, Housheng Hansen He
The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors. Nature communications 13 (1) (2022)
Shih Yu Cindy Yang, Trevor J Pugh, Amit M Oza
Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (13) (2022)
Patty Sachamitr, Jolene Caifeng Ho, Felipe E Ciamponi, Wail Ba-Alawi, Fiona J Coutinho, Paul Guilhamon, Michelle M Kushida, Florence M G Cavalli, Lilian Lee, Naghmeh Rastegar, Victoria Vu, Maria Sánchez-Osuna, Jasmin Coulombe-Huntington, Evgeny Kanshin, Heather Whetstone, Mathieu Durand, Philippe Thibault, Kirsten Hart, Maria Mangos, Joseph Veyhl, Wenjun Chen, Nhat Tran, Bang-Chi Duong, Ahmed M Aman, Xinghui Che, Xiaoyang Lan, Owen Whitley, Olga Zaslaver, Dalia Barsyte-Lovejoy, Laura M Richards, Ian J Restall, Amy A Caudy, Hannes L Röst, Zahid Quyoom Bonday, Mark Bernstein, Sunit Das, Michael D Cusimano, Julian Spears, Gary D Baider, Trevor J Pugh, Mike Tyers, Mathieu Lupien, Benjamin Haibe-Kains, H Artee Luchman, Samuel Weiss, Katlin B Massirer, Panagiotis Prinos, Cheryl H Arrowsmith, Peter B Dirks
PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature communications 12 (1) (2021)
Jeff P Bruce, Ka-Fai To, Vivian Wai Yan Lui, Grace T Y Chung, Yuk-Yu Chan, Chi Man Tsang, Kevin Y Yip, Brigette Buig Yue Ma, John K S Woo, Edwin Pun Hui, Michael K F Mak, Sau-Dan Lee, Chit Chow, Sharmila Velapasamy, Yvonne Y Y Or, Pui Kei Siu, Samah El Ghamrasni, Stephenie D Prokopec, Man Wu, Johnny S H Kwan, Yuchen Liu, Jason Ying-Kuen Chan, C Andrew van Hasselt, Lawrence S Young, Christopher W Dawson, Ian Charles Paterson, Lee Fah Yap, Sai-Wah Tsao, Fei-Fei Liu, Anthony T C Chan, Trevor J Pugh, Kwok-Wai Lo
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nature communications 12 (1) (2021)
Samah El Ghamrasni, Rene Quevedo, James R Hawley, Parisa Mazrooei, Youstina Hanna, Iulia Cirlan, Helen Zhu, Jeffrey P Bruce, Leslie E Oldfield, S Y Cindy Yang, Paul Guilhamon, Jüri Reimand, David W Cescon, Susan J Done, Mathieu Lupien, Trevor J Pugh
Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer. Molecular cancer research : MCR (2021)
Danielle C Croucher, Laura M Richards, Serges P Tsofack, Daniel D Waller, Zhihua Li, Ellen Nong Wei, Xian Fang Huang, Marta Chesi, Peter Leif Bergsagel, Michael Sebag, Trevor J Pugh, Suzanne Trudel
Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression. Nature communications 12 (1) (2021)
Brittany B Campbell, Melissa A Galati, Simone C Stone, Alexandra N Riemenschneider, Melissa Edwards, Sumedha Sudhaman, Robert Siddaway, Martin Komosa, Nuno Miguel Nunes, Liana Nobre, A Sorana Morrissy, Matthew Zatzman, Michal Zapotocky, Lazar Joksimovic, Sangeetha N Kalimuthu, David Samuel, Gary Mason, Eric Bouffet, Daniel A Morgenstern, Melyssa Aronson, Carol Durno, David Malkin, John M Maris, Michael D Taylor, Adam Shlien, Trevor J Pugh, Pamela S Ohashi, Cynthia E Hawkins, Uri Tabori
Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition. Cancer discovery 11 (6) (2021)
Victor H Ferreira, Andrzej Chruscinski, Vathany Kulasingam, Trevor J Pugh, Tamara Dus, Brad Wouters, Amit Oza, Matthew Ierullo, Terrance Ku, Beata Majchrzak-Kita, Sonika T Humar, Ilona Bahinskaya, Natalia Pinzon, Jianhua Zhang, Lawrence E Heisler, Paul M Krzyzanowski, Bernard Lam, Ilinca M Lungu, Dorin Manase, Krista M Pace, Pouria Mashouri, Michael Brudno, Michael Garrels, Tony Mazzulli, Myron Cybulsky, Atul Humar, Deepali Kumar
Prospective observational study and serosurvey of SARS-CoV-2 infection in asymptomatic healthcare workers at a Canadian tertiary care center. PloS one 16 (2) (2021)
Daniel Vilarim Araújo, Ao Wang, Dax Torti, Alberto Leon, Kayla Marsh, Aoife McCarthy, Hal K Berman, Anna Spreafico, Aaron R Hansen, Albiruni-Abdul Razak, Philippe L Bedard, Lisa Wang, Eric Plackmann, Helen Chow, Hua Bao, Xue Wu, Trevor J Pugh, Lillian L Siu
Applications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy. JNCI cancer spectrum 5 (3) (2021)
Eric Leung, Kathy Han, Jinfeng Zou, Zhen Zhao, Yangqiao Zheng, Ting Ting Wang, Ariana Rostami, Lillian L Siu, Trevor J Pugh, Scott V Bratman
HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (21) (2021)
Kenneth C Anderson, Daniel Auclair, Stacey J Adam, Amit Agarwal, Melissa Anderson, Herve Avet-Loiseau, Mark Bustoros, Jessica R Chapman, Dana E Connors, Ajeeta B Dash, Alessandra Di Bacco, Ling Du, Thierry Facon, Juan A Flores-Montero, Francesca Gay, Irene M Ghobrial, Nicole J Gormley, Ira Gupta, Howard Higley, Jens Hillengass, Bindu Kanapuru, Dickran Kazandjian, Gary J Kelloff, Ilan R Kirsch, Brandon E Kremer, Carl Ola Landgren, Elizabeth D Lightbody, Oliver C Lomas, Sagar Lonial, Maria Victoria Mateos, Rocio Montes de Oca, Lata Mukundan, Nikhil C Munshi, Elizabeth K O'Donnell, Alberto Orfao, Bruno Paiva, Reshma Patel, Trevor J Pugh, Karthik Ramasamy, Jill Ray, Mikhail Roshal, Jeremy A Ross, Caroline C Sigman, Katie L Thoren, Suzanne Trudel, Gary A Ulaner, Nancy Valente, Brendan M Weiss, Elena Zamagni, Shaji K Kumar
Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration. Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Laura M Richards, Owen K N Whitley, Graham MacLeod, Florence M G Cavalli, Fiona J Coutinho, Julia E Jaramillo, Nataliia Svergun, Mazdak Riverin, Danielle C Croucher, Michelle Kushida, Kenny Yu, Paul Guilhamon, Naghmeh Rastegar, Moloud Ahmadi, Jasmine K Bhatti, Danielle A Bozek, Naijin Li, Lilian Lee, Clare Che, Erika Luis, Nicole I Park, Zhiyu Xu, Troy Ketela, Richard A Moore, Marco A Marra, Julian Spears, Michael D Cusimano, Sunit Das, Mark Bernstein, Benjamin Haibe-Kains, Mathieu Lupien, H Artee Luchman, Samuel Weiss, Stephane Angers, Peter B Dirks, Gary D Baider, Trevor J Pugh
Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity. Nature cancer 2 (2) (2021)
S Y Cindy Yang, Scott C Lien, Ben X Wang, Derek L Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P Bruce, Samah El Ghamrasni, Marco A J Iafolla, Marc Oliva, Aaron R Hansen, Anna Spreafico, Philippe L Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G Brooks, Tracy L McGaha, Marcus O Butler, Scott V Bratman, Pamela S Ohashi, Lillian L Siu, Trevor J Pugh
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. Nature communications 12 (1) (2021)
Sagi Abelson, Andy G X Zeng, Ido Nofech-Mozes, Ting Ting Wang, Stanley W K Ng, Mark D Minden, Trevor J Pugh, Philip Awadalla, Liran I Shlush, Tracy Murphy, Steven M Chan, John E Dick, Scott V Bratman
Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing. Science advances 6 (50) (2020)
Ravindra Uppaluri, Katie M Campbell, Ann Marie Egloff, Paul Zolkind, Zachary L Skidmore, Brian Nussenbaum, Randal C Paniello, Jason T Rich, Ryan Jackson, Patrik Pipkorn, Loren S Michel, Jessica Ley, Peter Oppelt, Gavin P Dunn, Erica K Barnell, Nicholas C Spies, Tianxiang Lin, Tiantian Li, David T Mulder, Youstina Hanna, Iulia Cirlan, Trevor J Pugh, Tenny Mudianto, Rachel Riley, Liye Zhou, Vickie Y Jo, Matthew D Stachler, Glenn J Hanna, Jason Kass, Robert Haddad, Jonathan D Schoenfeld, Evisa Gjini, Ana Lako, Wade Thorstad, Hiram A Gay, Mackenzie Daly, Scott J Rodig, Ian S Hagemann, Dorina Kallogjeri, Jay F Piccirillo, Rebecca D Chernock, Malachi Griffith, Malachi Griffith, Douglas R Adkins
Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (19) (2020)
Ian J Restall, Orsolya Cseh, Laura M Richards, Trevor J Pugh, H Artee Luchman, Samuel Weiss
Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway. Cancer research 80 (24) (2020)
Branavan Manoranjan, Chitra Venugopal, David Bakhshinyan, Ashley A Adile, Laura M Richards, Michelle M Kameda-Smith, Owen Whitley, Anna Dvorkin-Gheva, Minomi Subapanditha, Neil Savage, Nazanin Tatari, Dillon McKenna, Blessing Bassey-Archibong, Neil Winegarden, Robin Hallett, John P Provias, Blake Yarascavitch, Olufemi Ajani, Adam J Fleming, Gary D Baider, Trevor J Pugh, Bradley W Doble, Sheila K Singh
Wnt activation as a therapeutic strategy in medulloblastoma. Nature communications 11 (1) (2020)
Stanley Zhou, James R Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N Yamaguchi, Shadrielle M G Espiritu, Yanyun Zhu, Tesa M Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus H Van der Kwast, Trevor J Pugh, Michael Fraser, Paul C Boutros, Robert G Bristow, Housheng Hansen He, Mathieu Lupien
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Nature communications 11 (1) (2020)
Scott V Bratman, S Y Cindy Yang, Marco A J Iafolla, Zhihui Liu, Aaron R Hansen, Philippe L Bedard, Stephanie Lheureux, Anna Spreafico, Albiruni Abdul Razak, Svetlana Shchegrova, Maggie Louie, Paul Billings, Bernhard Zimmermann, Himanshu Sethi, Alexey Aleshin, Dax Torti, Kayla Marsh, Jenna Eagles, Iulia Cirlan, Youstina Hanna, Derek L Clouthier, Scott C Lien, Pamela S Ohashi, Wei Xu, Lillian L Siu, Trevor J Pugh
Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab. Nature cancer 1 (9) (2020)
Stephanie Lheureux, Ana Oaknin, Swati Garg, Jeffrey P Bruce, Ainhoa Madariaga, Neesha C Dhani, Valerie Bowering, Justin White, Sarah Accardi, Qian Tan, Marsela Braunstein, Katherine Karakasis, Iulia Cirlan, Stephanie Pedersen, Tiantiam Li, Lorena Fariñas-Madrid, Yeh Chen Lee, Zhihui Amy Liu, Trevor J Pugh, Amit M Oza
EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (16) (2020)
Marie Jo Halaby, Kebria Hezaveh, Sara Lamorte, M Teresa Ciudad, Andreas Kloetgen, Bethany L MacLeod, Mengdi Guo, Ankur Chakravarthy, Tiago da Silva Medina, Stefano Ugel, Aristotelis Tsirigos, Vincenzo Bronte, David H Munn, Trevor J Pugh, Daniel D De Carvalho, Marcus O Butler, Pamela S Ohashi, David G Brooks, Tracy L McGaha
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment. Science immunology 4 (42) (2020)
Marco A J Iafolla, Cindy Yang, Vinod Chandran, Melania Pintilie, Quan Li, Philippe L Bedard, Aaron Hansen, Stephanie Lheureux, Anna Spreafico, Albiruni A Razak, Sevan Hakgor, Amanda Giesler, Trevor J Pugh, Lillian L Siu
Predicting Toxicity and Response to Pembrolizumab Through Germline Genomic HLA Class 1 Analysis. JNCI cancer spectrum 5 (1) (2020)
Sampath Kumar Loganathan, Krista Schleicher, Ahmad Malik, Rene Quevedo, Ellen Langille, Katie Teng, Robin H Oh, Bhavisha Rathod, Ricky Tsai, Payman Samavarchi-Tehrani, Trevor J Pugh, Anne-Claude Gingras, Daniel Schramek
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science (New York, N.Y.) 367 (6483) (2020)
David T Mulder, Etienne R Mahé, Mark Dowar, Youstina Hanna, Tiantian Li, Linh T Nguyen, Marcus O Butler, Naoto Hirano, Jan Delabie, Pamela S Ohashi, Trevor J Pugh
CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling. Blood advances 2 (23) (2019)
Soroush Samadian, Jeff P Bruce, Trevor J Pugh
Bamgineer: Introduction of simulated allele-specific copy number variants into exome and targeted sequence data sets. PLoS computational biology 14 (3) (2018)
Olena Kis, Rayan Kaedbey, Signy Chow, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Esther Masih-Khan, Tong Zhang, Scott V Bratman, Amit M Oza, Suzanne Kamel-Reid, Suzanne Trudel, Trevor J Pugh
Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates. Nature communications 8 (2017)
Sarah Q Crome, Linh T Nguyen, Sandra Lopez-Verges, S Y Cindy Yang, Bernard Martin, Jennifer Y Yam, Dylan J Johnson, Jessica Nie, Michael Pniak, Pei Hua Yen, Anca Milea, Ramlogan Sowamber, Sarah Rachel Katz, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Philipp A Lang, Hal K Berman, Trevor J Pugh, Lewis L Lanier, Pamela S Ohashi
A distinct innate lymphoid cell population regulates tumor-associated T cells. Nature medicine 23 (3) (2017)
Sameer Agnihotri, Suganth Suppiah, Peter D Tonge, Shahrzad Jalali, Arnavaz Danesh, Jeffery P Bruce, Yasin Mamatjan, George Klironomos, Lior Gonen, Karolyn Au, Sheila Mansouri, Sharin Karimi, Felix Sahm, Andreas von Deimling, Michael D Taylor, Normand J Laperriere, Trevor J Pugh, Kenneth D Aldape, Gelareh Zadeh
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas. Nature communications 8 (1) (2017)
Haiyang Guo, Musaddeque Ahmed, Fan Zhang, Cindy Q Yao, SiDe Li, Yi Liang, Junjie Hua, Fraser Soares, Yifei Sun, Jens Langstein, Yuchen Li, Christine Poon, Swneke D Bailey, Kinjal Desai, Teng Fei, Qiyuan Li, Dorota H Sendorek, Michael Fraser, John R Prensner, Trevor J Pugh, Mark Pomerantz, Robert G Bristow, Mathieu Lupien, Felix Y Feng, Paul C Boutros, Matthew L Freedman, Martin J Walsh, Housheng Hansen He
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nature genetics 48 (10) (2016)
Swneke D Bailey, Kinjal Desai, Ken J Kron, Parisa Mazrooei, Nicholas A Sinnott-Armstrong, Aislinn E Treloar, Mark Dowar, Kelsie L Thu, David W Cescon, Jennifer Silvester, S Y Cindy Yang, Xue Wu, Rossanna C Pezo, Benjamin Haibe-Kains, Tak W Mak, Philippe L Bedard, Trevor J Pugh, Richard C Sallari, Mathieu Lupien
Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer. Nature genetics 48 (10) (2016)
Trevor J Pugh, Sami S Amr, Mark J Bowser, Sivakumar Gowrisankar, Elizabeth D Hynes, Lisa M Mahanta, Michael J Bamshad, Birgit Funke, Matthew S Lebo
VisCap: inference and visualization of germ-line copy-number variants from targeted clinical sequencing data. Genetics in medicine : official journal of the American College of Medical Genetics 18 (7) (2015)