The association between C-reactive protein, mood disorder, and cognitive function in UK Biobank.

David C MiltonJoey WardEmilia WardDonald M LyallRona Juliette Strawbridge Daniel J Smith Breda Cullen

Published in: European psychiatry : the journal of the Association of European Psychiatrists (2021)

In this large cohort study, we found that measured inflammation was associated with mood disorder history, but genetic predisposition to inflammation was not. The association between mood disorder and worse cognitive performance was very small and did not vary by CRP level. The inconsistent relationship between CRP measures and cognitive performance warrants further study.

Keyphrases

bipolar disorder
oxidative stress
sleep quality
genome wide
gene expression
cross sectional
copy number
dna methylation
depressive symptoms