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Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans.

Ernest Diez BenaventeRobin J G HartmanTim R SakkersMarian WesselingYannicke SlootsLotte SlendersArjan BoltjesBarend M MolGert J de BorstDominique P V de KleijnKoen H M PrangeMenno P J de WintherJohan KuiperMete CivelekSander W van der LaanSteve HorvathN Charlotte Onland-MoretMichal MokryGerard PasterkampHester M den Ruijter
Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Plaque EAA is a strong and independent marker of poor outcome in patients with severe atherosclerosis. Plaque EAA was linked to mesenchymal endothelial and smooth muscle cells. Endothelial-to-mesenchymal transition was associated with EAA, which was experimentally validated. Epigenetic aging mechanisms may provide new targets for treatments that reduce atherosclerosis complications.
Keyphrases
  • poor prognosis
  • bone marrow
  • stem cells
  • endothelial cells
  • coronary artery disease
  • long non coding rna
  • dna methylation
  • cardiovascular disease
  • gene expression
  • early onset
  • risk factors
  • type diabetes