Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature.

Hanbi KimHyun Tae KimJi Hye Lee Hyonseok Hwang Duk Keun An

Published in: RSC advances (2020)

An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room temperature. In addition, DFT calculations for a plausible reaction pathway are reported.

Keyphrases

room temperature
ionic liquid
solid state
density functional theory
randomized controlled trial
molecular dynamics
molecular dynamics simulations
highly efficient
molecular docking