A case of progressive multifocal leukoencephalopathy under dimethyl fumarate treatment without severe lymphopenia or immunosenescence.

Martin DieboldValerian AltersbergerBernhard F DécardLudwig KapposTobias DerfussJohannes Lorscheider

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)

Despite risk stratification, vigilance for PML is advised in all pwMS under DMF. Severe CD8-lymphopenia is a common feature of all published DMF-associated cases.

Keyphrases

early onset
multiple sclerosis
machine learning
drug induced
randomized controlled trial
systematic review
combination therapy
replacement therapy