Angiotensin II receptor blocker irbesartan attenuates sleep apnea-induced cardiac apoptosis and enhances cardiac survival and Sirtuin 1 upregulation.
Pei-Ying PaiYi-Yuan LinShao-Hong YuChing-Yuang LinYi-Fan LiouXu-Bo WuJames K S WongChih-Yang HuangShin-Da LeePublished in: Sleep & breathing = Schlaf & Atmung (2021)
Our findings suggest that the ARB may prevent cardiac Fas/FasL to mitochondrial apoptotic pathways and enhance cardiac IGF1/PI3K/AKT pro-survival pathway in the sleep apnea model associated with JNK de-activation and SIRT1 upregulation. ARB prevents chronic sleep apnea-enhanced cardiac apoptosis via enhancing survival pathways.
Keyphrases
- sleep apnea
- pi k akt
- positive airway pressure
- signaling pathway
- angiotensin ii
- cell cycle arrest
- left ventricular
- cell death
- obstructive sleep apnea
- oxidative stress
- cell proliferation
- endoplasmic reticulum stress
- poor prognosis
- angiotensin converting enzyme
- mouse model
- high glucose
- binding protein
- ischemia reperfusion injury