Efficacy and safety of tyrosine kinase inhibitors in patients with metastatic pheochromocytomas/paragangliomas：A systematic review and meta-analysis.

Yue ZhouYunying CuiDing-Ding Zhang Anli Tong

Published in: The Journal of clinical endocrinology and metabolism (2022)

This meta-analysis suggests that patients with metastatic PPGLs can benefit from TKIs therapy with PR and DCR up to more than 30% and 80%. However, because of restricted studies, larger clinical trials should be performed in the future.

Keyphrases

case control
systematic review
clinical trial
meta analyses
current status
phase ii
randomized controlled trial
chronic myeloid leukemia
stem cells
open label
bone marrow
cell therapy
phase iii
smoking cessation