Complexities and Perplexities: A Critical Appraisal of the Evidence for Soil-Transmitted Helminth Infection-Related Morbidity.

Suzy J CampbellSusana V NerySuhail A DoiDarren J GrayRicardo J Soares MagalhãesJames S McCarthyRebecca J TraubRoss M AndrewsArchie C A Clements

Published in: PLoS neglected tropical diseases (2016)

Overall, the Cochrane systematic review and recent studies indicate major shortfalls in evidence for direct morbidity. However, it is questionable whether the systematic review methodology should be applied to STH due to heterogeneity of the prevalence of different species in each setting. Urgent investment in studies powered to detect direct morbidity effects due to STH is required.

Keyphrases

systematic review
meta analyses
risk factors
case control
randomized controlled trial
single cell