Amino acid substitution L232F in non-structural protein 6 identified as a possible human-adaptive mutation in clade B MERS coronaviruses.
Ray T Y SoDaniel K W ChuKenrie P Y HuiChris K P MokMarcus H H ShumSumana SanyalJohn M NichollsJohn C W HoMan-Chun CheungKa-Chun NgHin-Wo YeungMichael C W ChanLeo L M PoonJin-Cun ZhaoTommy T Y LamJoseph S Malik PeirisPublished in: Journal of virology (2023)
. Our results showed that nsp6 L232F may be an adaptive mutation associated with zoonotic transmission of MERS-CoV. This study highlighted the capacity of MERS-CoV to adapt to transmission to humans and also the need for continued surveillance of MERS-CoV in camels.