CD33 modulates TREM2: convergence of Alzheimer loci.
Gail ChanCharles C WhitePhoebe A WinnMaria CimpeanJoseph M ReplogleLaura R GlickNicole E CuerdonKatie J RyanKeith A JohnsonJulie A SchneiderDavid A BennettLori B ChibnikReisa A SperlingElizabeth M BradshawPhilip L De JagerPublished in: Nature neuroscience (2015)
We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.