Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial.
Jens-Ulrik Stæhr JensenTheis S ItenovKatrin M ThormarLars HeinThomas T MohrMads H AndersenJesper LøkenHamid TousiBettina LundgrenHans Christian BoesenMaria E JohansenSisse R OstrowskiPär I JohanssonJesper GrarupJørgen VestboJens D Lundgrennull nullPublished in: Annals of intensive care (2016)
Early profound alveolar damage in intubated patients can be identified by SPD blood measurement at intensive care admission, and high SPD level is a strong independent predictor that the patient suffers from ARDS and will not recover independent respiratory function within one month. This knowledge can be used to improve diagnostic and prognostic models and to identify the patients who most likely will benefit from experimental interventions aiming to preserve alveolar tissue and therefore respiratory function. Trial registration This is a sub-study to the Procalcitonin And Survival Study (PASS), Clinicaltrials.gov ID: NCT00271752, first registered January 1, 2006.
Keyphrases
- respiratory failure
- mechanical ventilation
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- end stage renal disease
- emergency department
- healthcare
- case report
- oxidative stress
- clinical trial
- ejection fraction
- chronic kidney disease
- newly diagnosed
- physical activity
- study protocol
- intensive care unit
- randomized controlled trial
- drug induced
- patient reported outcomes
- patient reported
- artificial intelligence
- open label
- placebo controlled
- free survival
- cone beam