GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma.
Mónica P de AndrésRichard J JacksonIrene FelipeSladjana ZagoracChristian PilarskyAnna Melissa SchlitterJaime Martinez de VillarealGun Ho JangEithne CostelloSteve GallingerPaula GhanehWilliam GreenhalfThomas KnöselDaniel H PalmerPetra RuemmeleWilko WeichertMarkus BuechlerThilo HackertJohn P NeoptolemosFaiyaz NottaNúria MalatsPaola MartinelliFrancisco X RealPublished in: Gut (2022)
cooperate to maintain the classical phenotype. Our findings provide compelling rationale to assess their expression as biomarkers of poor prognosis and therapeutic response.