Expression of the Autoantigen Topoisomerase-1 is Enriched in the Lung Tissues of Patients With Autoimmune Interstitial Lung Disease: A Case Control Study.

Tricia R CottrellFrederic AskinMarc K HalushkaLivia A Casciola-Rosen Zsuzsanna H McMahan

Published in: ACR open rheumatology (2020)

Pulmonary expression of topoisomerase-1 is increased in the setting of autoimmune ILD relative to normal lung, specifically in pneumocytes. This may contribute to the amplification of pulmonary disease in patients with scleroderma with a loss of tolerance to topoisomerase-1.

Keyphrases

interstitial lung disease
systemic sclerosis
poor prognosis
rheumatoid arthritis
idiopathic pulmonary fibrosis
pulmonary hypertension
multiple sclerosis
gene expression
binding protein