Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1/Smad2-Mediated Endothelial-to-Mesenchymal Transition.

Ya-Ge JinYuan YuanQing-Qing WuNing ZhangDi FanYan CheZhao-Peng WangYang XiaoSha-Sha WangQi-Zhu Tang

Published in: PPAR research (2017)

Puerarin protected against TAC-induced cardiac fibrosis, and this protective effect may be attributed to the upregulation of PPAR-γ and the inhibition of TGF-β1/Smad2-mediated EndMT.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
left ventricular
stem cells
bone marrow
high glucose
diabetic rats
signaling pathway
poor prognosis
insulin resistance
heart failure
adipose tissue
drug induced
oxidative stress