Association and expression of the antigen-processing gene PSMB8, coding for low-molecular-mass protease 7, with vitiligo in North India: case-control study.

P DaniN PatnaikA SinghA JaiswalB AgrawalA A KumarS R VarkhandeA SharmaU VaishSomesh GuptaV K SharmaP SharmaG VermaH K KarS GuptaV T NatarajanR S GokhaleRajni Rani

Published in: The British journal of dermatology (2017)

The PSMB8 exon 2 SNP is significantly associated with vitiligo. Accumulation of ubiquitinated proteins in skin of cases of vitiligo suggests their aberrant processing, which may promote the development of the disease.

Keyphrases

genome wide
poor prognosis
copy number
soft tissue
high density
transcription factor
genome wide identification
genetic diversity