Fatty acid synthesis is indispensable for Kupffer cells to eliminate bacteria in ALD progression.

Liuyu XieBeng WuYuanyuan FanYe TaoXiaoyong JiangQing LiHuaiping ZhuHua Wang Chaojie Hu

Published in: Hepatology communications (2024)

Our findings indicate the crucial role of de novo lipogenesis in maintaining effective KCs phagocytosis and suggest a therapeutic target for ALD based on fatty acid synthesis in KCs.

Keyphrases

fatty acid
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
type diabetes
cell proliferation
skeletal muscle