The potential impacts of early secreted antigenic target of 6 kDa of Mycobacterium tuberculosis on KSHV-infected cells.
Lu DaiBock-Gie JungJungang ChenBuka SamtenJames Craig ForrestSteven R PostZhiqiang QinPublished in: Journal of medical virology (2020)
Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers, including Kaposi's sarcoma (KS) and primary effusion lymphoma, which are mostly seen in immunocompromised patients, such as human immunodefeciency virus (HIV)+ individuals. Tuberculosis (TB), caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb), remains one of the deadliest infectious diseases in the world. The risk of developing TB is dramatically higher in people living with HIV than among those without HIV infection. Case reports link cutaneous or pulmonary KS in HIV+ patients with mycobacterial co-infections, however, impacts of Mtb infection or its products on KSHV-infected cells are not known. We report here that ESAT-6, a secreted Mtb virulence factor, induces viral reactivation from KSHV-infected cells. KSHV-infected pulmonary endothelial cells were resistant to ESAT-6 induced inhibition of cell growth. Our data demonstrate that Mtb virulence factors influence the biology of KSHV-infected cells, highlighting the need to study the interactions between these two pathogens commonly found in people living with HIV.
Keyphrases
- mycobacterium tuberculosis
- induced apoptosis
- pulmonary tuberculosis
- endothelial cells
- cell cycle arrest
- antiretroviral therapy
- escherichia coli
- pulmonary hypertension
- staphylococcus aureus
- end stage renal disease
- human immunodeficiency virus
- endoplasmic reticulum stress
- hiv infected
- emergency department
- chronic kidney disease
- pseudomonas aeruginosa
- young adults
- infectious diseases
- signaling pathway
- hiv aids
- antimicrobial resistance
- electronic health record
- ejection fraction
- sars cov
- case report
- cell death
- induced pluripotent stem cells
- multidrug resistant
- prognostic factors
- risk assessment
- mechanical ventilation
- artificial intelligence
- pluripotent stem cells