Probing the Limits of Selectivity in a Recognition-Mediated Reaction Network Embedded within a Dynamic Covalent Library.
Tamara KosikovaHarry MackenzieDouglas PhilpPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2015)
Two recognition-mediated reaction processes operating through reactive binary complexes drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and the strength of the recognition processes employed in the dynamic system.